Organizations working in global health now have access to a significant funding opportunity through the Advancing Global Health (AGH) Program, launched by the U.S. Department of State through its Bureau of Global Health Security and Diplomacy (GHSD). This initiative is designed to support projects that strengthen health systems, improve health outcomes, and promote sustainable, country-led health programs worldwide. With an estimated $4.5 billion in total funding, the program aims to expand global health efforts and accelerate progress toward saving lives and improving healthcare resilience. Overview of the Advancing Global Health Program The AGH Program provides grants and cooperative agreements to organizations implementing large-scale global health initiatives. The program prioritizes projects that build stronger national health systems and increase countries’ ability to independently manage public health challenges. By supporting innovative partnerships and scalable interventions, the initiative aims to improve healthcare delivery, enhance disease prevention strategies, and strengthen global health security. Key Program Details Funding Opportunity Number: DFOP0017890 Funding Type: Grant or Cooperative Agreement Project Duration: Up to 5 years Estimated Number of Awards: Up to 100 Grant Size: $500,000 to $250 million per project Total Estimated Funding: Up to $4.5 billion (subject to availability) This funding opportunity represents one of the largest global health initiatives currently available to international organizations and institutions. Who Can Apply? The program is open to a wide range of organizations involved in health, development, and humanitarian work. Eligible applicants include: U.S. and international nonprofit organizations Universities and higher education institutions Private sector companies Faith-based organizations Public international organizations Government institutions The diversity of eligible applicants reflects the program’s emphasis on multi-sector partnerships and collaborative solutions to global health challenges. Application Process Applications for the AGH Program follow a two-phase process designed to identify the most impactful and scalable proposals. Phase 1: Statement of Interest (SOI) Applicants must first submit a Statement of Interest (SOI) outlining their proposed initiative. The concept note should be no more than 5 pages (approximately 2,500 words) and should include: A description of the problem being addressed The proposed solution or intervention Expected outcomes and impact Key partners and stakeholders involved Importantly, the SOI must respond to specific Addenda published under the funding opportunity. General submissions that do not align with these addenda will not be reviewed. Phase 2: Full Proposal Applicants whose concept notes are selected will be invited to submit a full proposal. This stage requires detailed program plans, budgets, implementation strategies, and monitoring frameworks. Application Deadlines The AGH Program uses a rolling submission process with multiple application windows. Submission Windows Window 1: 5 March – 31 May 2026 Window 2: 1 June – 14 August 2026 Window 3: 15 August – 14 November 2026 Window 4: 15 November 2026 – 14 February 2027 This flexible timeline allows organizations to prepare high-quality submissions and align proposals with relevant addenda. Focus on Sustainable Global Health Systems The Advancing Global Health Program is designed to support projects that not only address immediate health challenges but also build long-term capacity within national health systems. The initiative emphasizes: Strengthening public health infrastructure Supporting country-led health programs Expanding partnerships between governments and organizations Promoting sustainability and self-reliance in healthcare systems Through these efforts, the program aims to contribute to improved health outcomes and stronger global health security. How to Learn More and Apply Organizations interested in applying can access the full program details and application portal through the official funding page. Applicants can also contact the program team directly for questions regarding eligibility, application procedures, or addenda requirements. A Major Opportunity for Global Health Organizations With billions of dollars in potential funding and up to 100 awards expected, the AGH Program represents a major opportunity for organizations working to improve healthcare access and outcomes worldwide. By supporting innovative solutions and collaborative partnerships, the initiative aims to advance global health priorities and ensure that countries have the tools and systems needed to protect and improve the health of their populations. For more opportunities such as these please follow us on Facebook, Instagram, WhatsApp, Twitter, LinkedIn and WPChannel Disclaimer: Global South Opportunities (GSO) is not the organization that is offering this funding. For any inquiries, please contact the official organization directly. Please do not send your applications & CVs to GSO, as we are unable to process them. Due to the high volume of emails, we receive daily, we may not be able to respond to all inquiries. Thank you for your understanding.