The European Commission, through the Horizon Europe framework and Global Health EDCTP3 Joint Undertaking, has launched a major funding opportunity focused on climate change and health in sub-Saharan Africa (SSA). The call, titled Global Collaboration Action on Climate and Health in sub-Saharan Africa, seeks to address the growing burden of climate-sensitive infectious diseases through international, interdisciplinary research and innovation. This two-stage Research and Innovation Action (RIA) aims to strengthen global health security while advancing equitable, evidence-based solutions that benefit vulnerable populations in SSA and, where relevant, Europe. Programme Overview and Key Dates The call is part of Horizon Europe under the Global Health EDCTP3 programme and supports large-scale collaborative research initiatives. Key details include: Programme: Horizon Europe (HORIZON) Type of action: Research and Innovation Action (RIA) Submission model: Two-stage Stage 1 deadline: 4 March 2026 Stage 2 deadline: 17 September 2026 Total indicative budget: EUR 25 million Expected number of funded projects: Approximately five Proposals must demonstrate strong scientific excellence, measurable impact, and effective implementation capacity. Rationale and Strategic Context Climate change is already affecting an estimated 3.6 billion people globally, with projections indicating approximately 250,000 additional deaths per year between 2030 and 2050 due to climate-related health impacts. Although Africa contributes minimally to global emissions, it experiences a disproportionate share of climate-linked health emergencies. In sub-Saharan Africa: Over half of public health emergencies in the past two decades were climate-related Water-borne diseases accounted for approximately 40% of these events Vector-borne and zoonotic diseases continue to rise Vulnerable populations, including women, children, displaced communities, and low-income households, are most affected These trends underscore the urgency of coordinated international research aligned with the European Commission’s Strategic Research and Innovation Agenda on Health and Climate Change. Expected Impact and Outcomes Funded projects are expected to contribute to: Reduced burden of climate-sensitive water- and vector-borne diseases in SSA Progress toward Sustainable Development Goals 3 (Good Health and Well-being) and 13 (Climate Action) Strengthened international research collaboration and resource mobilisation Expected outcomes include: Improved health outcomes for climate-sensitive infectious diseases in SSA and, where applicable, Europe Enhanced evidence-based decision-making for climate-health policies Increased engagement of communities and primary health care systems in disease prevention and control Scope and Research Requirements Proposals must include at least one major research component and meet comprehensive inclusion criteria. Mandatory research components (minimum one): Phase IIb, III, or IV clinical trials for preventive or therapeutic medicines or vaccines Large-scale implementation research on validated medical devices or novel vector control interventions Additional required elements: Integration of One Health approaches linking human, animal, and environmental health Engagement with primary health care systems and community health workers Inclusion of underserved and vulnerable populations, such as children under five, pregnant women, elderly individuals, immunocompromised persons, and displaced populations Further requirements (at least two): Inclusion of indigenous populations where relevant Assessment of climate impacts on medical supply chains Active involvement of policymakers and health authorities Alignment with national climate adaptation and health emergency plans Adaptation of primary health care systems to climate stressors Preclinical studies are excluded, except where preparatory activities directly enable eligible clinical research. Consortium Composition and Governance Consortia must reflect strong representation from sub-Saharan Africa and Europe. Minimum consortium requirements: At least three independent legal entities from different eligible countries At least one beneficiary from an EU Member State or associated country At least one beneficiary from a sub-Saharan African EDCTP Association member country Where the project coordinator is not based in SSA, a scientific project leader from an SSA country must be appointed to oversee scientific governance and leadership. Funding, Contributions, and Access Obligations Projects must leverage financial and/or in-kind contributions from contributing partners, with transparent budgeting and activity descriptions. Awarded projects are subject to affordability and access obligations, ensuring that resulting health technologies are: Accessible Available Affordable under fair and reasonable conditions Applicants must submit an access plan outlining regulatory, manufacturing, intellectual property, and distribution strategies, particularly for low-resource settings. Collaboration, Networking, and Knowledge Translation Funded projects are strongly encouraged to: Participate in joint networking and knowledge-sharing activities Collaborate with existing EDCTP networks, adaptive platform trials, and research initiatives Translate research findings into public health practice and policy using established toolkits Multidisciplinary approaches integrating health, climate science, nutrition, and WASH sectors are highly encouraged. 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