Open Philanthropy is expanding its Global Catastrophic Risks (GCR) division to address some of the world’s most urgent challenges — from biosecurity and pandemic preparedness to transformative artificial intelligence (AI). The organization seeks up to four senior generalists to strengthen leadership capacity, drive strategic projects, and enhance global impact across its fast-growing portfolio. About the Global Catastrophic Risks Division The GCR division is responsible for reducing the likelihood and impact of large-scale global threats. It encompasses programs in Navigating Transformative AI, Biosecurity and Pandemic Preparedness, GCR Capacity Building, and Forecasting, alongside other special initiatives. With more than $500 million in grants projected for 2025, Open Philanthropy anticipates continued growth in both scale and complexity. To meet these evolving demands, the organization is hiring talented leaders with strong strategic thinking, project management, and stakeholder engagement skills. These roles offer a rare opportunity to shape global responses to long-term, high-stakes risks. The Four Key Roles Chief of Staff, Global Catastrophic Risks Working directly with senior leaders Emily Oehlsen and George Rosenfeld, this role supports overall strategy, coordination, and leadership across the GCR division. The Chief of Staff will help set strategic direction, enhance team alignment, and identify new opportunities for expansion. The position offers close collaboration with senior executives and a platform for leadership growth. Chief of Staff, Technical AI Safety Reporting to Peter Favaloro, this position supports the Technical AI Safety (TAIS) program, which funds research to mitigate catastrophic risks from advanced AI systems. The role focuses on scaling a rapidly growing team, streamlining operations, and driving cross-functional initiatives. While technical expertise is not required, familiarity with AI safety or research management is advantageous. The successful candidate will help shape systems, strategies, and talent pipelines to maximize the program’s global influence. Chief of Staff, Short Timelines Special Projects This newly established role supports Claire Zabel in leading initiatives designed for scenarios where transformative AI develops faster than expected. The Chief of Staff will drive high-impact projects, navigate ambiguity, and act with speed and precision to identify interventions that could be critical in short-timeline contexts. Candidates who are agile, analytical, and comfortable with uncertainty will thrive in this dynamic environment. Associate Program Officer, AI Governance & Policy Reporting to Alex Lawsen, this position supports the AI Governance and Policy program, which works to strengthen global preparedness for transformative AI. The Associate Program Officer may focus on grantmaking development, identifying new opportunities, or supporting team management and growth. Ideal candidates will be detail-oriented, proactive, and motivated to enhance the impact of the world’s leading AI governance funders. Common Responsibilities Across Roles Across all positions, successful candidates will act as trusted advisors and collaborators, supporting senior leaders in decision-making, strategic planning, and project delivery. Core responsibilities include: Strategic input on priorities and decision-making Driving key initiatives and leading special projects Stakeholder management with internal teams and external partners Operational support to improve organizational efficiency Each role offers autonomy and responsibility, with opportunities to grow into leadership or specialized areas over time. Candidate Profile Open Philanthropy seeks individuals who demonstrate exceptional judgment, organization, and leadership. Ideal candidates will be strategic thinkers with experience managing complex projects or teams in fields such as consulting, operations, policy, or research management. Additional qualities include: Strong written and verbal communication Ability to manage competing priorities A service-oriented mindset and collaborative spirit Familiarity with AI safety, biosecurity, or global catastrophic risk fields (preferred) While relevant experience is valued, Open Philanthropy emphasizes potential and encourages applications from individuals who do not meet every listed qualification. Working at Open Philanthropy Open Philanthropy offers a flexible, supportive environment where staff are empowered to pursue ambitious global good. Benefits include comprehensive health insurance, generous paid time off, family leave, and support for remote work. The organization embraces diverse perspectives and is committed to creating an inclusive, mission-driven culture that values openness, ownership, and continuous learning. Positions are open globally, with flexibility for remote or hybrid arrangements. Compensation is competitive and varies by experience and location, typically ranging between $170,000 and $200,000 annually, with additional retirement contributions. Application Process Candidates may apply for multiple roles through a single application. The process includes a written application, remote work test (with honoraria), and interviews. Finalists may participate in in-person sessions, with travel expenses covered. Applications close at 11:59 p.m. Pacific Time on Thursday, November 20, with offers expected by early 2026. Open Philanthropy may use AI-assisted tools to support early application review, but all decisions are made by human evaluators. Candidates can opt out of AI-assisted review by contacting the recruitment team directly. For full details and to apply, visit the Open Philanthropy careers page. For more opportunities such as these please follow us on Facebook, Instagram , WhatsApp, Twitter, LinkedIn and Telegram Disclaimer: Global South Opportunities (GSO) is not the hiring organization. For any inquiries, please contact the official organization directly. Please do not send your applications to GSO, as we are unable to process them. Due to the high volume of emails, we receive daily, we may not be able to respond to all inquiries. Thank you for your understanding.